Some PFCs are persistent compounds, ubiquitous in the environment, and human exposure is common ( Agency for Toxic Substances and Disease Registry 2009). Polyfluoroalkyl compounds (PFCs) are used in the production of fluoropolymers, which have applications in protective coatings of packaging products, clothes, furniture, and nonstick cookware. In addition, those with higher exposure to PFOS were larger at 20 months. No differences in weight were found for PFOA and PFHxS.Ĭonclusions: Girls with higher prenatal exposure to each of the PFCs examined were smaller at birth than those with lower exposure. At 20 months, however, girls born to mothers with prenatal concentrations of PFOS in the upper tertile weighed 580 g more (95% CI: 301, 858) when compared with those in the lower tertile. On average, girls born to mothers with prenatal concentrations of PFOS in the upper tertile weighed 140 g less at birth than girls born to mothers with concentrations in the lower tertile in adjusted models. Results: PFOS (median, 19.6 ng/mL), PFOA (median, 3.7 ng/mL), and PFHxS (median, 1.6 ng/mL) were detected in 100% of samples. We explored associations between prenatal PFC concentrations and weight at birth as well as longitudinal changes in weight-for-age SD scores between birth and 20 months. Serum samples were obtained in 1991–1992, from mothers during pregnancy. Data on weight and length were obtained at birth and at 2, 9, and 20 months. Methods: We studied a sample of 447 singleton girls and their mothers participating in the Avon Longitudinal Study of Parents and Children (ALSPAC). Objective: We explored associations of prenatal serum concentrations of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexane sulfonate (PFHxS) with fetal and postnatal growth in girls. Background: Prenatal exposures to polyfluoroalkyl compounds (PFCs) may be associated with adverse changes in fetal and postnatal growth.
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